Where it all began !

 
 
'The Czech Republic'

 Photos & graphics with permission

Synopsis: It all began here in the Czech Republic and this ‘spotlight focus’ gives an insight into the academic activities of Institute of Animal Physiology and Genetics and Centre of Cell Therapy and Tissue Replacement, as well as the ambiance and aspirations.

 

 

                                   

President:

RNDr. Hana Kovářová, CSc.

Institute of Animal Physiology and Genetics and Centre of Cell Therapy and Tissue Replacement
Rumburská 89
277 21 Liběchov
Tel. (+420) 315639582
Fax: (+420) 315697186
e-mail: kovarova@iapg.cas.cz                                                                                                                        

 

 

Institution of the Czechoslovak Academy of Sciences (CZAS) was the beginning of what now is the Institute of Animal Physiology and Genetics (IAPG) of the Czech Republic since 1st January 1993 after the country underwent political changes and so did the Institute.  Wonderful reminiscence of the past stand as iconic landmarks in the grounds of the Institution about its animal husbandry and research including the ‘horse heads’ on the walls of the Institute and the magnificent bandstand.

                        

 

 

Liběchov sits in Central Bohemian Region of the Czech Republic located about 36 km north of Prague on right bank of the Elbe River, approximately in half way between towns of Mělník and Štětí.

 

 

                 

 

 

During discussions over a glass of wine and with a beer mat as a notepad, the concept of Central and Eastern Proteomic Conference (CEEPC) was born out of a dire need to understand mechanisms regulating transcription, translation, protein-protein interactions and protein functionality in diseases.  It was more than a decade ago that the Founders of CEEPC Hana Kovarova and Suresh Jivan Gadher visualized the indispensable need for both proteomics and a forum to discuss proteomics. The term Central and Eastern European Proteomic Conference (CEEPC) was coined by Hana, Suresh and Josef Chmelik (1953-2007), who sadly passed away in July prior to the inaugral Conference in October 2007. 

    

Since then, CEEPC’s ‘2020 Vision’ has come true as it stands established as a Proteomic Conference of importance.  Additionally, CEEPC has come a long way not only for its proteomics but also for embracing humanity and nurturing societal needs. Careful balancing of proteomic excellence with evolving urgent global medical and societal needs, has ushered in its present-day success.  

 

                                                                 

On going reseach

Huntington’s disease

Huntington’s disease is a hereditary neurodegeneration with an autosomal dominant inheritance. Mutation in a huntingtin gene leads to huntingtin protein aggregation and cellular toxicity, with horrendous outcome for the patient.

Using transgenic minipig model of Huntington’s disease, we are studying changes in protein levels connected to the disease progression to uncover changes that could contribute to better understanding of the pathogenesis.  Aim remains to identifying protein alterations in blood plasma, cerebrospinal fluid and changes to immune response including the complement system, cytokines and possibly uncover biomarkers of disease progression.

 

Neural stem cells

Neural stem cells can play a major role in cell replacement therapies of the nervous system as well as act as a useful cell model for research into neural cell differentiation during nervous system development.  We are studying changes in protein composition of cell surface proteins of the neural stem cells and their differentiated progenies (neurons, astrocytes and oligodendrocytes) with the aim of identifying markers usable for specific sorting and selection of desired cell population. Additionally, our interest includes research on secreted proteins and exosomes and their function in stem cell niche and cell differentiation.

 

Melanoma

Melanoma originates from malignant transformation of pigmented cells called melanocytes.  Using our transgenic minipig model with hereditary melanoma (Melanoma-bearing Libechov Minipig, MeLiM), we are focused on the mechanisms of this malignance and potential implications in clinical immunotherapy of melanoma as well as a search for potential therapeutics to combat this cancer.

 

                                                             

                                                              Hana & Jan Motlik 

 

 

Knedlíky

 

 

 

 

Smažený Sýr

 

 

Fried bramboráky (potato pancakes)

 

 

Guláš