Poland & Proteomic Research

CEEPC Country Focus: 'Poland'

Capital - Warsaw

Synopsis:

In keeping with CEEPC intentions and ethos, Poland was invited to join the CEEPC in 2013 and has now hosted the CEEP conference in Poland for the second time; the first one being the 9th CEEPC in Poznań in 2015. This second Conference - the 13th CEEPC was successfully hosted in Ustron in September 2019. This ‘spot-light focus’ gives an insight into 'Proteomics & Poland'

CEEPC Representative: Prof. Piotr Widlak, Ph.D. / Chairman of the Center for Translational Research and Molecular Biology of Cancer

Maria Sklodowska-Curie Institute - Oncology Center, Gliwice Branch
44-101 Gliwice, Poland; phone: +48-32-2789672

Logo & Pictures - with permission

Piotr Widak Lab – Clinical Proteomics Group :

http://cd.io.gliwice.pl/en/groups/proteomics/

Current Research Projects:

1) Metabolomics and radiomics signature of early lung cancer (NCN; 2017/27/B/NZ7/01833; PI – P. Widlak)

2) Intratumor heterogeneity and its role in cancer progression and prognosis; a study based on molecular imaging of cancer by MALDI-MSI (NCN; 2016/23/B/NZ4/03901; PI – P. Widlak)

3) Molecular profiling of tumor-derived exosomes in plasma of patients with melanoma (NCN; 2016/22/M/NZ5/00667; PI – M. Pietrowska)

Current (International) Collaborations:

1) Prof. Theresa L. Whiteside (Pittsburgh, USA) – extracellular vesicles and immunology

2) Prof. Marek Kimmel (Houston, USA) – biostatistics and mathematical modeling

3) Prof. Michael D. Story (Dallas, USA) – radiation biology and biomarkers

Publications: (three most recent publications)

1) Bednarczyk K, Gawin M, Chekan M, Kurczyk A, Mrukwa G, Pietrowska M, Polanska J, Widlak P: Discrimination of normal oral mucosa from oral cancer by mass spectrometry imaging of proteins and lipids. J Mol Histol. 2019;50:1-10. PMID:30390197

2) Abramowicz A, Wojakowska A, Marczak L, Lysek-Gladysinska M, Smolarz M, Story MD, Polanska J, Widlak P, Pietrowska M: Ionizing radiation affects the composition of the proteome of extracellular vesicles released by head-and-neck cancer cells in vitro. J Radiat Res. 2019;60:289-297. PMID:30805606

3) Ludwig S, Marczak L, Sharma P, Abramowicz A, Gawin M, Widlak P, Whiteside TL, Pietrowska M: Proteomes of exosomes from HPV(+) or HPV(-) head and neck cancer cells: differential enrichment in immunoregulatory proteins. Oncoimmunology. 2019;8:1593808. PMID:31143515.

Keywords: cancer biomarkers; clinical proteomics and metabolomics; extracellular vesicles; mass spectrometry imaging & signaling pathways.